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Yes You’ve Read It Correctly! If you’re using nitrate supplements to increase your nitric oxide levels on race day, using antibacterial mouthwash can have a detrimental effect on nitric oxide production! Recap of the Nitrate-Nitrite-Nitric Oxide Pathway When ingested, nitrate circulates in blood plasma whilst approximately 25% is concentrated in saliva after being taken up by the salivary glands (Spiegelhalder et al., 1976). Anaerobic bacteria on the tongue is then responsible for the reduction of nitrate into nitrite (Govoni et al., 2008). Once swallowed, some of the nitrite is reduced to form nitric oxide in the acidic conditions of the stomach, whilst...

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